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KMID : 0811720130170040359
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Korean Journal of Physiology & Pharmacology
2013 Volume.17 No. 4 p.359 ~ p.365
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Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse
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Hong Seung-Hwa
Sung Ro-Hyun
Kim Young-Chul
Hikaru Suzuki
Choi Woong
Park Yeon-Jin
Ji Ill-Woon
Kim Chan-Hyung
Myung Sun-Chul
Lee Moo-Yeol
Kang Tong-Mook
You Ra-Young
Lee Kwang-Ju
Lim Seung-Woon
Yun Hyo-Yung
Song Young-Jin
Xu Wen-Xie
Kim Hak-Soon
Lee Sang-Jin
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Abstract
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Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K＋ channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, K＋ conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibitors such as quinidine, lidocaine, and extracellular acidosis produced contraction in uterine circular muscle of mouse. Furthermore, contractility was significantly increased in pregnant uterine circular muscle than that of non-pregnant muscle. These patterns were not changed even in the presence of tetraetylammonium (TEA) and 4-aminopyridine (4-AP). Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretch- activated channels in myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed increased immunohistochemical expression of TASK-2. Therefore, TASK-2, seems to play a key role during regulation of myometrial contractility in the pregnancy and provides new insight into preventing preterm delivery.
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KEYWORD
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Relaxation, TASK-2, Uterus
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